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KMID : 0369820100400050277
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Jorunal of Korean Pharmaceutical Sciences
2010 Volume.40 No. 5 p.277 ~ p.283
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Enhanced Dissolution of Coenzyme Q10 using Solid Dispersions Prepared by Low Temperature Melting Method
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Kang Jun-Heok
Yan Yi-Dong
Kim Hyun-Chan
Lee Sung-Neung
Yong Chul-Soon
Choi Han-Gon
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Abstract
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CoQ with low melting temperature was exploited to improve its solubility by preparing its solid dispersions (SDs) with a meltable polymer, poloxamer 407 (P 407). P407 can be utilized for a relatively simple, quick, inexpensive, reproducible and potentially scalable manner in the low temperature melting method. CoQ 10 solubility and dissolution increased with increasing concentrations of P 407 in SDs. Comparison of the enhanced dissolution of CoQ 10 from different poloxamers suggested that the preparation of CoQ 10 SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its dissolution.
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KEYWORD
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Coenzyme Q10, Poloxamer 407, Solid dispersion, Solubility, Dissolution
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